Aslı Kutlu completed her undergraduate studies in 2012 at the department of Chemical and Biological Engineering at Koç University. In 2012, she started her PhD at the department of Molecular Biology, Genetics and Bioengineering. Sabancı University, under the supervision of Prof. Uğur Sezerman. Her research studies are about the protein engineering application of cellulase and lipase enzymes from the perspective of both experimental and computation point of view. After receiving PhD at 2017, she works as post-doctoral fellow at Acıbadem Mehmet Aydınlar University, Department of Medical Statistics and Bioinformatics, School of Medicine, where she again joined to Sezerman Lab. During the post-doctoral fellowship, she mostly focused on the investigation of rare disease mechanism through molecular dynamics (MD) studies to elucidate the roles of novel mutations. In 2019 February, she started to work at Biruni University as Assistant Professor. Now, she has joined to İstinye University, the department of molecular biology and genetics. Still, her research studies are about the investigation of rare disease mechanism through MD studies and the identification of novel genes as potential biomarkers for Head-and-Neck cancer and Cholangiocarcinoma. Aslı Kutlu is the author of 6 articles and she is a principle investigator of TUBITAK-1002 project and a researcher in several BAP-projects.
Araştırma Alanları
- Biyoinformatik
- Protein Engineering
- Protein Biochemistry
- Bioinformatics Analysis
- Medical Genetics
- Molecular Genetics
- Modeling and Simulation
Çalışma Alanları
- Fen Bilimleri ve Matematik Temel Alanı
- Moleküler Biyoloji ve Genetik
- Biyoteknoloji
- Moleküler Biyoloji
- Biyoenformatik
- TNFRSF13B VARIANTS ACT AS MODIFIERS TO CLINICAL PHENOTYPES IN COMMON VARIABLE IMMUNE DEFICIENCY DISORDERS, 2023
- Repurposing Fc gamma receptor I (FcγRI, CD64) for site-oriented monoclonal antibody capture: A proof-of-concept study for real-time detection of tumor necrosis factor-alpha (TNF -α), 2023
- Identification of key genes and pathways for cholangiocarcinoma using an integrated bioinformatics analysis, 2022
- Discussing the roles of proline and glycine from the perspective of cold adaptation in lipases and cellulases, 2022
- Computational analysis of missense filamin-A variants, including the novel p.Arg484Gln variant of two brothers with periventricular nodular heterotopia., 2022
- Identifying and elucidating the roles of Y198N and Y204F mutations in the PAH enzyme through molecular dynamic simulations, 2021
- Performing the comparative analysis to understand the functional roles of genes in different pathways of cardiomyopathy disease, 2021
- Understanding the impacts of self-shuffling approach on structure and function of shuffled endoglucanase enzyme via MD simulations, 2020
- Elucidating the roles of naturally occurring silent mutations in Polycystic Ovary Syndrome (PCOS), 2020
- A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia, 2019
- Enhancing Enzymatic Properties of Endoglucanase I Enzyme from Trichoderma Reesei via Swapping from Cellobiohydrolase I Enzyme, 2019
- Investigating the structural properties of the active conformation BTL2 of a lipase from Geobacillus thermocatenulatus in toluene using molecular dynamic simulations and engineering BTL2 via in-silico mutation, 2018
- Desing and characterization of two novel cellulases through single gene shuffling of Cel12A (EG3) gene from Trichoderma reesei, 2016
- Yaygın Değişken İmmün Yetersizliklerde Tüm Genom Metilasyon Değişimlerinin İncelenmesi, 2024
- Hydrogen Bond Fingerprints: Revealing the Complexities of Protein Function, 2023
- Generation of novel cellulases and lipases for industrial applications through DNA shuffling and molecular dynamic simulations,
- “MASP2 geninde meydana gelen sessiz varyantların biyoinformatik analizi, 2021
- Explaining the Different Forms of Primer Immunodeficiency (PID) Caused by Missense Variants in RAG1 Gene from Structural Perspective , 2022
- How To Use Big Data In Health Informatics For Discovery Of Diagnostics and Prognostic Biomarkers In Cancer?, 2022
- How To Utilize Gene Expression Omnibus (GEO) Data Sets In Pathway-Based Biomarker Studies: Cholangiocarcinoma Case, 2022
- Head and Neck cancer: performing functional gene enrichment and clustering study to discover the new potentials as biomarker, 2020
- Database application on cardiomyopathy, 2020
- Using a decision tree meta-predictor and accelerated molecular dynamics method together to predict the functional impacts of variants, 2020
- Kolanjiokarsinomda secili genlerin potansiyel biyobelirtec rollerinin hesaplamali yaklasimla yeniden gozden gecirilmesi,
- Probing for potential genes as novel biomarkers in head-and-neck cancer: prognostic and diagnostic approach, 2022
- Probing The Structural Impacts Of Arg388 Replacements In Pkp2 Protein Complex: Spesıfıc Case In Arvc, 2022
- Bioinformatics Approach Of The Effect Of Radıochemotherapy Treatment On Gene Expression,
- Revealing the structural impacts of point mutations on MeCP2 protein associated with Rett Syndrome via MD Simulations, 2020
- Head-and-neck cancer: performin functional gene enrichment and clustering study to discover the new potentials as biomarker, 2021
- SCRAPIE RELATED MUTATIONSANALYSES OF SHEEP PRION PROTEIN VIA MOLECULAR DYNAMICS SIMULATIONS, 2020
- Analysis of Cold-Adaptive Lipases with Molecular Dynamics Simulations, 2020
- The investigation of activation mechanism of BTL2 in non-aqueous solvents, 2014
- Generation of cellulases for industrial applications through DNA shuffling, 2015
- An attempt to improve the accuracy of mutation impact prediction through molecular dynamics studies, 2019
- An attempt to identify the potential biomarkers in the Bladder Cancer via functional gene-enrichment approach, 2019
- Head-and-neck cancer: Performing functional gene enrichment study to discover the new potentials as biomarkers, 2019
- Head-and-neck cancer: Performing functional gene enrichment study to discover the new potentials as biomarker, 2019
- Gene enrichment analysis to elucidate the role of mitochondrial genes in prostate cancer, 2019
- Moleküler Biyoloji Güncel Araştırma Teknikleri, ISBN: 978-625-7849-52-4, 2022
- TÜM YÖNLERİYLE DİL VE KONUŞMA BOZUKLUKLARINDA DEĞERLENDİRME, ISBN: 978-625-399-460-0, 2023