Faculty Member, PhD
Aslı Kutlu
Moleküler Biyoloji ve Genetik
Aslı Kutlu completed her undergraduate studies at the Department of Chemical and Biological Engineering at Koç University in 2012. In 2012, she started her Ph.D. studies at the Department of Molecular Biology, Genetics and Bioengineering. Sabancı University under the supervision of Prof. Uğur Sezerman. Her research studies are about protein engineering for industrial applications. After receiving her Ph.D. in 2017, she worked as a post-doctoral fellow at Acıbadem Mehmet Aydınlar University, Department of Medical Statistics and Bioinformatics, School of Medicine, where she joined the Sezerman lab again. During the postdoctoral fellowship, she mainly focused on studying the mechanism of rare diseases through molecular dynamics (MD) studies to elucidate the role of novel mutations. Between February 2019 and August 2020, she worked at Biruni University as an assistant professor. In September 2020, she joined the ISU Department of Molecular Biology and Genetics as a PI in the field of molecular cancer research and rare disease mechanism through experimental and computational approaches.
Araştırma Alanları
- Protein Engineering
- Bioinformatics Analysis
- Modeling and Simulation
- Cancer Biology
- Anticancer Drug Development
- Molecular Genetics
Çalışma Alanları
- Fen Bilimleri ve Matematik Temel Alanı
- Moleküler Biyoloji ve Genetik
- Biyoteknoloji
- Moleküler Biyoloji
- Biyoenformatik
- Fc–FcγRI Complexes: Molecular Dynamics Simulations Shed Light on Ectodomain D3′s Potential Role in IgG Binding, 2024
- TNFRSF13B VARIANTS ACT AS MODIFIERS TO CLINICAL PHENOTYPES IN COMMON VARIABLE IMMUNE DEFICIENCY DISORDERS, 2023
- Repurposing Fc gamma receptor I (FcγRI, CD64) for site-oriented monoclonal antibody capture: A proof-of-concept study for real-time detection of tumor necrosis factor-alpha (TNF -α), 2023
- Identification of key genes and pathways for cholangiocarcinoma using an integrated bioinformatics analysis, 2022
- Discussing the roles of proline and glycine from the perspective of cold adaptation in lipases and cellulases, 2022
- Computational analysis of missense filamin-A variants, including the novel p.Arg484Gln variant of two brothers with periventricular nodular heterotopia., 2022
- Identifying and elucidating the roles of Y198N and Y204F mutations in the PAH enzyme through molecular dynamic simulations, 2021
- Performing the comparative analysis to understand the functional roles of genes in different pathways of cardiomyopathy disease, 2021
- Elucidating the roles of naturally occurring silent mutations in Polycystic Ovary Syndrome (PCOS), 2020
- Understanding the impacts of self-shuffling approach on structure and function of shuffled endoglucanase enzyme via MD simulations, 2020
- A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia, 2019
- Enhancing Enzymatic Properties of Endoglucanase I Enzyme from Trichoderma Reesei via Swapping from Cellobiohydrolase I Enzyme, 2019
- Investigating the structural properties of the active conformation BTL2 of a lipase from Geobacillus thermocatenulatus in toluene using molecular dynamic simulations and engineering BTL2 via in-silico mutation, 2018
- Desing and characterization of two novel cellulases through single gene shuffling of Cel12A (EG3) gene from Trichoderma reesei, 2016
- Hydrogen Bond Fingerprints: Revealing the Complexities of Protein Function, 2023
- Modeling Structural Properties and Thermostability of the Active Conformation of Lipase from Geobacillus Thermocatenulatus, BTL2, in Organic Solvent., 2017
- Yaygın Değişken İmmün Yetersizliklerde Tüm Genom Metilasyon Değişimlerinin İncelenmesi, 2024
- Generation of novel cellulases and lipases for industrial applications through DNA shuffling and molecular dynamic simulations,
- “MASP2 geninde meydana gelen sessiz varyantların biyoinformatik analizi, 2021
- Explaining the Different Forms of Primer Immunodeficiency (PID) Caused by Missense Variants in RAG1 Gene from Structural Perspective , 2022
- How To Use Big Data In Health Informatics For Discovery Of Diagnostics and Prognostic Biomarkers In Cancer?, 2022
- How To Utilize Gene Expression Omnibus (GEO) Data Sets In Pathway-Based Biomarker Studies: Cholangiocarcinoma Case, 2022
- Head and Neck cancer: performing functional gene enrichment and clustering study to discover the new potentials as biomarker, 2020
- Database application on cardiomyopathy, 2020
- Using a decision tree meta-predictor and accelerated molecular dynamics method together to predict the functional impacts of variants, 2020
- Kolanjiokarsinomda secili genlerin potansiyel biyobelirtec rollerinin hesaplamali yaklasimla yeniden gozden gecirilmesi,
- Probing for potential genes as novel biomarkers in head-and-neck cancer: prognostic and diagnostic approach, 2022
- Probing The Structural Impacts Of Arg388 Replacements In Pkp2 Protein Complex: Spesıfıc Case In Arvc, 2022
- Bioinformatics Approach Of The Effect Of Radıochemotherapy Treatment On Gene Expression,
- Revealing the structural impacts of point mutations on MeCP2 protein associated with Rett Syndrome via MD Simulations, 2020
- Head-and-neck cancer: performin functional gene enrichment and clustering study to discover the new potentials as biomarker, 2021
- SCRAPIE RELATED MUTATIONSANALYSES OF SHEEP PRION PROTEIN VIA MOLECULAR DYNAMICS SIMULATIONS, 2020
- Analysis of Cold-Adaptive Lipases with Molecular Dynamics Simulations, 2020
- The investigation of activation mechanism of BTL2 in non-aqueous solvents, 2014
- Generation of cellulases for industrial applications through DNA shuffling, 2015
- An attempt to improve the accuracy of mutation impact prediction through molecular dynamics studies, 2019
- An attempt to identify the potential biomarkers in the Bladder Cancer via functional gene-enrichment approach, 2019
- Head-and-neck cancer: Performing functional gene enrichment study to discover the new potentials as biomarkers, 2019
- Head-and-neck cancer: Performing functional gene enrichment study to discover the new potentials as biomarker, 2019
- Gene enrichment analysis to elucidate the role of mitochondrial genes in prostate cancer, 2019
- Lippincott’s Illustrated Reviews: Biochemistry, Eighth Edition, ISBN: ISBN: 978-1-9751-5506-3, 2024
- Lippincott’s Illustrated Reviews: Biochemistry, Eighth Edition, ISBN: ISBN: 978-1-9751-5506-3, 2024
- Metabolic Syndrome: A compherensive update with new insights, ISBN: 978-981-5322-13-2, 2025
- Moleküler Biyoloji Güncel Araştırma Teknikleri, ISBN: 978-625-7849-52-4, 2022
- TÜM YÖNLERİYLE DİL VE KONUŞMA BOZUKLUKLARINDA DEĞERLENDİRME, ISBN: 978-625-399-460-0, 2023