Mühendislik ve Doğa Bilimleri Fakültesi

Akademik Kadro

Doç. Dr. Ali Zarrabi

Doç. Dr.
Ali Zarrabi

Biyomedikal Mühendisliği

Dr. Ali Zarrabi is Associate Professor and Principal Investigator in the Biomedical Engineering Department of Istinye University. He holds a bachelor's degree of Chemical Engineering from Isfahan University of Technology, a master's degree of Chemical Engineering from Sharif University of Technology, and a PhD of Nanobiotechnology from Sharif University of Technology. His current research interests include nanobiotechnology, nanomedicine, drug delivery systems, nanotheranostics, nanomaterials, and surface engineering/modifications of nanomaterials. His group works at the interface of supramolecular chemistry, bioengineering, and medicine to develop approaches for simultaneous diagnosis and treatment of diseases. Dr. Zarrabi is a member of editorial board of several journals such as "Journal of Personalized medicine", "Bioengineering", "Future Pharmacology", "Biomaterials and Polymers Horizon", and "Nanofabrication".

Araştırma Alanları

  • Nanomedicine
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials
  • Theranostic Therapy
  • Nano Based Therapeutics Geliştirilmesi
  • Sağlıkta Nanoteknoloji
  • Cancer
  • Neurodegenrative Disease
  • Alzheimer's Disease
  • Parkinson's disease
  • Glioblastoma; GBM

Çalışma Alanları

  • Mühendislik Temel Alanı
  • Biyomedikal Mühendisliği
  • Biyomalzeme
  • Biyoteknoloji
  • Nanoteknoloji
  • Application of Convergent Science and Technology toward Ocular Disease Treatment, 2023
  • (Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy, 2023
  • Graphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosis, 2023
  • Advancements and Applications of Upconversion Nanoparticles in Wound Dressings, 2023
  • Cancer stem cell-mediated drug resistance: A comprehensive gene expression profile analysis in breast cancer, 2023
  • Biosensor integrated brain on a chip platforms: Progress and prospects in clinical translation, 2023
  • Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment, 2023
  • Biomedical applications of engineered heparin-based materials, 2023
  • Biosensor integrated brain-on-a-chip platforms: Progress and prospects in clinical translation, 2023
  • Application of Convergent Science and Technology toward Ocular Disease Treatment, 2023
  • Biosensor integrated brain-on-a-chip platforms: Progress and prospects in clinical translation, 2023
  • Tackling chronic wound healing using nanomaterials: advancements, challenges, and future perspectives, 2023
  • Application of Convergent Science and Technology toward Ocular Disease Treatment, 2023
  • AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation, 2022
  • Combination therapy using nanomaterials and stem cells to treat spinal cord injuries, 2022
  • EZH2 as a new therapeutic target in brain tumors: Molecular landscape, therapeutic targeting and future prospects, 2022
  • (Nano)platforms in bladder cancer therapy: Challenges and opportunities, 2022
  • Targeting AMPK signaling in ischemic/reperfusion injury: From molecular mechanism to pharmacological interventions, 2022
  • Gene regulation by antisense transcription: A focus on neurological and cancer diseases, 2022
  • Noncoding RNAs and their therapeutics in paclitaxel chemotherapy: Mechanisms of initiation, progression, and drug sensitivity, 2022
  • Development of Lateral Flow Assays for Rapid Detection of Troponin I: A Review, 2022
  • Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments, 2022
  • Combination therapy using nanomaterials and stem cells to treat spinal cord injuries, 2022
  • Association analysis of rs1800470 (T869C) variation in TGFB1 gene with the risk of ischemic stroke in Asian population, 2022
  • Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments, 2022
  • Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments, 2022
  • Emerging role of exosomes in cancer progression and tumor microenvironment remodeling, 2022
  • Graphene oxide quantum dot-chitosan nanotheranostic platform as a pH-responsive carrier for improving curcumin uptake internalization: In vitro & in silico study, 2022
  • Nanotechnological Approaches in Prostate Cancer Therapy: Integration of engineering and biology, 2022
  • Long noncoding RNAs (lncRNAs) in pancreatic cancer progression, 2022
  • Chitosan-based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy, 2022
  • Immunology Meets Bioengineering: Improving the Effectiveness of Glioblastoma Immunotherapy, 2022
  • Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling, 2022
  • The convergence of in silico approach and nanomedicine for efficient cancer treatment; in vitro investigations on curcumin loaded multifunctional graphene oxide nanocomposite structure, 2022
  • Exosomes as Promising Nanostructures in Diabetes Mellitus: From Insulin Sensitivity to Ameliorating Diabetic Complications, 2022
  • The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review, 2022
  • AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation, 2022
  • Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response, 2022
  • Long non-coding RNAs as new players in bladder cancer: Lessons from pre-clinical and clinical studies, 2022
  • Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects, 2022
  • Chitosan: A versatile bio-platform for breast cancer theranostics, 2022
  • Mesoporous silica@chitosan@gold nanoparticles as \u201con/off\u201d optical biosensor and pH-sensitive theranostic platform against cancer, 2022
  • Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: Stimuli-responsive carriers, co-delivery and suppressing resistance, 2022
  • Targeted regulation of autophagy using nanoparticles: New insight into cancer therapy, 2022
  • Targeting autophagy, oxidative stress, and ER stress for neurodegenerative diseases treatment, 2022
  • Overcoming doxorubicin resistance in cancer: siRNA-loaded nanoarchitectures for cancer gene therapy, 2022
  • Characterization and optical properties of mechanochemically synthesized molybdenum-doped rutile nanoparticles and their electronic structure studies by density functional theory, 2022
  • The long and short non-coding RNAs modulating EZH2 signaling in cancer, 2022
  • Exploiting Urazole’s Acidity for Fabrication of Hydrogels and Ion-Exchange Materials, 2021
  • Citrus Genus and Its Waste Utilization: A Review on Health-Promoting Activities and Industrial Application, 2021
  • Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management, 2021
  • Lycopene: Food Sources, Biological Activities, and Human Health Benefits, 2021
  • Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli\u2010Responsive, Toxicity, Immunogenicity, and Clinical Translation, 2021
  • Revealing the role of miRNA-489 as a new onco-suppressor factor in different cancers based on pre-clinical and clinical evidence, 2021
  • Functionalization of polymers and nanomaterials for water treatment, food packaging, textile and biomedical applications: a review, 2021
  • Curcumin and inflammatory bowel diseases: From in vitro studies to clinical trials, 2021
  • Lung cancer cells and their sensitivity/resistance to cisplatin chemotherapy: Role of microRNAs and upstream mediators, 2021
  • Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance, 2021
  • Flavonoids against the SARS-CoV-2 induced inflammatory storm, 2021
  • Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects, 2021
  • Electrospun nanocarriers for delivering natural products for cancer therapy, 2021
  • Citrus Genus and Its Waste Utilization: A Review on Health-Promoting Activities and Industrial Application, 2021
  • Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies, 2021
  • Pre-clinical investigation of STAT3 pathway in bladder cancer: Paving the way for clinical translation, 2021
  • Artemisia species as a new candidate for Diabetes therapy: A Comprehensive Review, 2021
  • Quercetin and Its Nano-Scale Delivery Systems in Prostate Cancer Therapy: Paving the Way for Cancer Elimination and Reversing Chemoresistance, 2021
  • Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies, 2021
  • MicroRNAs regulating SOX2 in cancer progression and therapy response, 2021
  • The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators, 2021
  • Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: New insight to proliferation and metastasis, 2021
  • Novel strategy in breast cancer therapy: Revealing the bright side of ginsenosides, 2021
  • Curcumin and inflammatory bowel diseases: From in vitro studies to clinical trials, 2021
  • Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers, 2021
  • Naringenin Nano-Delivery Systems and Their Therapeutic Applications, 2021
  • Crosstalk of long non-coding RNAs and EMT: Searching the missing pieces of an incomplete puzzle for lung cancer therapy, 2021
  • Current Trends in the Therapeutic Strategies for Diabetes Management, 2021
  • Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery, 2021
  • The role of SOX family transcription factors in gastric cancer, 2021
  • Synthesis of Curcumin Loaded Smart pH-Responsive Stealth Liposome as a Novel Nanocarrier for Cancer Treatment, 2021
  • Injectable hyaluronic acid-based antibacterial hydrogel adorned with biogenically synthesized AgNPs-decorated multi-walled carbon nanotubes, 2021
  • Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems, 2021
  • Long non-coding RNAs in the doxorubicin resistance of cancer cells, 2021
  • Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: Approaching to a new era of cancer chemotherapy, 2021
  • Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management, 2021
  • Nonspherical Metal\u2010Based Nanoarchitectures: Synthesis and Impact of Size, Shape, and Composition on Their Biological Activity, 2021
  • Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery, 2021
  • Long noncoding RNAs: A novel insight in the leukemogenesis and drug resistance in acute myeloid leukemia, 2021
  • Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects, 2021
  • Revealing the role of miRNA-489 as a new onco-suppressor factor in different cancers based on pre-clinical and clinical evidence, 2021
  • Long non-coding RNAs as new players in bladder cancer: Lessons from pre-clinical and clinical studies, 2021
  • Benzimidazole analogues as efficient arsenals in war against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studies, 2021
  • Role of ZEB family members in proliferation, metastasis and chemoresistance of prostate cancer cells: Revealing signaling networks, 2021
  • Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects, 2021
  • Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?, 2021
  • Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking, 2021
  • A review study on the modulation of SIRT1 expression by miRNAs in aging and age-associated diseases, 2021
  • Long non-coding RNAs in the doxorubicin resistance of cancer cells, 2021
  • AIE-featured tetraphenylethylene nanoarchitectures in biomedical application: Bioimaging, drug delivery and disease treatment, 2021
  • Design and characterization of a novel pH-sensitive biocompatible and multifunctional nanocarrier for in vitro paclitaxel release, 2021
  • Therapeutic potential of AMPK signaling targeting in lung cancer: Advances, challenges and future prospects, 2021
  • New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities, 2021
  • Antimicrobial peptides as potential therapeutics for breast cancer, 2021
  • Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management, 2021
  • Flavonoids against the SARS-CoV-2 induced inflammatory storm, 2021
  • Electroconductive multi-functional polypyrrole composites for biomedical applications, 2021
  • Interplay between SOX9 transcription factor and microRNAs in cancer, 2021
  • Nonspherical Metal\u2010Based Nanoarchitectures: Synthesis and Impact of Size, Shape, and Composition on Their Biological Activity, 2021
  • Effect of zinc-doped hydroxyapatite/graphene nanocomposite on the physicochemical properties and osteogenesis differentiation of 3D-printed polycaprolactone scaffolds for bone tissue engineering, 2021
  • Development and optimization of a new hybrid chitosan-grafted graphene oxide/magnetic nanoparticle system for theranostic applications, 2021
  • Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy, 2021
  • Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression, 2021
  • Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy, 2021
  • Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance, 2021
  • Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer, 2021
  • The involvement of epithelial-to-mesenchymal transition in doxorubicin resistance: Possible molecular targets, 2021
  • A reduced graphene oxide-β-cyclodextrin nanocomposite-based electrode for electrochemical detection of curcumin, 2021
  • Non-spherical nanostructures in nanomedicine: From noble metal nanorods to transition metal dichalcogenide nanosheets, 2021
  • In vivo gene delivery mediated by non-viral vectors for cancer therapy, 2020
  • An adhesive and injectable nanocomposite hydrogel of thiolated gelatin/gelatin methacrylate/Laponite (R) as a potential surgical sealant, 2020
  • Recent advances and future directions in anti\u2010tumor activity of cryptotanshinone: A mechanistic review, 2020
  • The ER Stress/UPR Axis in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis, 2020
  • New Horizons in Hydrogels for Methotrexate Delivery, 2020
  • Recent advances and future directions in anti\u2010tumor activity of cryptotanshinone: A mechanistic review, 2020
  • Hierarchical multifunctional graphene oxide cancer nanotheranostics agent for synchronous switchable fluorescence imaging and chemical therapy, 2020
  • Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects, 2020
  • Functionalization of polymers and nanomaterials for water treatment, food packaging, textile and biomedical applications: a review, 2020
  • Graphene oxide - silica composite aerogels as pharmaceutical nanocarriers, 2022
  • SPIONs as Nano-Theranostics Agents, ISBN: 978-981-10-3563-0, 2017